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Overview ..... Attachment ..... Reverse Transcription ..... Integration - Translation ..... Protease ..... Assembly

Human Immunodeficiency Virus (HIV)

Integration of Viral DNA

DNA Insertion

Once the viral RNA has been reverse-transcribed into a strand of DNA, the DNA can then be integrated (inserted) into the DNA of the lymphocyte. The virus has its own enzyme called "integrase" that facilitates incorporation of the viral DNA into the host cells DNA. The integrated DNA is called a provirus.

 


Transcription: Back to RNA

DNA->RNA Transcription

As long as the lymphocyte is not activated or "turned-on", nothing happens to the viral DNA. But if the lymphocyte is activated, transcription of the viral DNA begins, resulting in the production of multiple copies of viral RNA. This RNA codes for the production of the viral proteins and enzymes (translation) and will also be packaged later as new viruses.

 



Translation: RNA >>> Proteins

DNA->Protein Translation

There are only 9 genes in the HIV RNA. Those genes have the code necessary to produce structural proteins such as the viral envelope and core plus enzymes like reverse transcriptase, integrase, and a crucial enzyme called a protease.

 

 

Return to Overview of HIV Infection.


assembly and budding viral protease translation integration and transcription reverse transcription attachment HIV Infection Cycle

1. ATTACHMENT
Getting in

2. REVERSE TRANSCRIPTION
From viral RNA to DNA

3. INTEGRATION, TRANSCRIPTION
a. Viral DNA joins host DNA
b. Making multiple viral RNAs

4. TRANSLATION
Producing viral proteins

5. VIRAL PROTEASE
Cleaving viral proteins

6. ASSEMBLY & BUDDING
Getting out

   

 

 

 

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